Not recommended for known or suspected MRSA infections. Inhalational anthrax. Discontinue use if conspicuous drop in BP, convulsive seizures, hypersensitivity reactions, psychotic reactions occur. Patients on controlled Na diet. Clostridium difficile
-associated diarrhea; pseudomembraneous colitis; superinfection. Patients predisposed to seizures; G6PD deficiency, severe bullous skin reactions (eg, SJS, TEN), dysglycaemia, psychotic patients, history of psychiatric disease, peripheral neuropathy, myasthenia gravis, vision disorders. Congenital long QT syndrome, uncorrected electrolyte imbalance (eg, hypokalemia, hypomagnesemia), cardiac disease (eg, heart failure, MI, bradycardia). Photosensitisation. Avoid exposure to strong sunlight or artificial UV rays. High doses. Concomitant use w/ corticosteroids, theophylline, vit K antagonist eg, warfarin, class IA & III antiarrhythmics, TCAs, macrolides, antipsychotics. False -ve results in TB diagnosis. Hepatic necrosis, fatal hepatic failure. Renal impairment. Women. Elderly >60 yr.