Metastatic breast cancer. Advanced ovarian cancer in women who have failed a 1st-line platinum based chemotherapy regimen. AIDS-related Kaposi's sarcoma (KS) in patients w/ low CD4 counts (<200 CD4 lymphocytes/mm3
) & extensive mucocutaneous or visceral disease. 1st-line systemic chemotherapy or 2nd-line chemotherapy in AIDS-KS patients w/ disease progression or in patients intolerant to, prior combination systemic chemotherapy comprising of at least 2 of the following: Vinca alkaloid, bleomycin & standard doxorubicin (or other anthracyclines). In combination w/ bortezomib for progressive multiple myeloma in patients who have received at least 1 prior therapy & who have already undergone or unsuitable for bone marrow transplant.