Concise Prescribing Info
Chronic idiopathic constipation.
Dosage/Direction for Use
Adult : PO 24 mcg twice daily.
Dosage Details
Chronic idiopathic constipation
Adult: 24 mcg bid.
Should be taken with food.
History of mechanical GI obstruction.
Special Precautions
Safety has not been established in pregnant women. Not to be used in patients with severe diarrhoea.
Adverse Reactions
Dose-dependent nausea. Diarrhoea, abdominal distension, pain, flatulence and vomiting. Headache, dizziness, fatigue, dyspnoea, and peripheral oedema.
Description: Lupristone is a locally-acting chloride-channel activator that increases intestinal secretion. In doing so, it increases intestinal motility, thus aiding the passage of stool and relieve the symptoms associated with chronic idiopathic constipation.
Absorption: Absorption after oral admin is negligible.
Metabolism: Rapidly and extensively metabolised by carbonyl reductase, likely in the stomach and jejunum.
Store between 15-30°C.
Disclaimer: This information is independently developed by MIMS based on Lubiprostone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by
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