Minulet

Minulet

ethinylestradiol + gestodene

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Ethinylestradiol 30 mcg, gestodene 75 mcg
Indications/Uses
Dosage/Direction for Use
1 tab daily at about same time for 21 consecutive days, followed by 7-day tab-free interval. Each subsequent pack is started on the day after the tab-free interval.
Contraindications
Hypersensitivity. Current or history of DVT, thromboembolism & pancreatitis associated w/ severe hypertriglyceridemia. Cerebrovascular or CAD; thrombogenic valvulopathies & rhythm disorders; diabetes w/ vascular involvement; uncontrolled HTN; known or suspected breast carcinoma or estrogen-dependent neoplasia; hereditary or acquired thrombophilias; headache w/ focal neurological symptoms; undiagnosed vag bleeding. Hepatic adenomas or carcinoma or active liver disease. Known or suspected pregnancy.
Special Precautions
Not for protection against HIV infection or other STDs. Venous & arterial thrombosis & thromboembolism; ocular lesions; increased BP; cervical & breast cancer; migraine/headache; angioedema; carbohydrate & lipid effects; genital bleeding; depression; diarrhea &/or vomiting. Perform breast, liver, extremities & pelvic organ exam, pap smear prior to therapy. Smoking. Hepatic neoplasia/liver disease. Pregnancy. Not recommended during lactation. Not for premenarche & postmenopausal women.
Adverse Reactions
Headache including migraines; breakthrough bleeding/spotting. Vaginitis including candidiasis; mood changes including depression, changes in libido; nervousness, dizziness; nausea, vomiting, abdominal pain; acne; breast pain, tenderness, enlargement & secretion, dysmenorrhea, change in menstrual flow, cervical ectropion & secretion, amenorrhea; fluid retention/edema; increased/decreased wt.
Drug Interactions
Decreased serum ethinylestradiol conc w/ rifampicin, rifabutin, barbiturates, primidone, phenylbutazone, phenytoin, dexamethasone, griseofulvin, topiramate, some PIs, modafinil, St. John's wort, ritonavir, certain antibiotics eg, ampicillin, other penicillin & tetracyclines. Increased serum ethinylestradiol conc w/ atorvastatin, ascorbic acid, paracetamol, indinavir, fluconazole, troleandomycin. Increased plasma & tissue conc w/ cyclosporine, theophylline, corticosteroids. Decreased plasma & tissue conc w/ lamotigrine. Increased risk of galactorrhea w/ flunarizine. Increased risk of intrahepatic cholestasis w/ troleandomycin.
MIMS Class
Oral Contraceptives
ATC Classification
G03AA10 - gestodene and ethinylestradiol ; Belongs to the class of progestogens and estrogens in fixed combinations. Used as systemic contraceptives.
Presentation/Packing
Form
Minulet tab
Packing/Price
1 × 21's
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