In combination w/ ciclosporin microemulsion & corticosteroids for prophylaxis of acute transplant rejection in adult patients receiving allogenic renal transplant.
Monitor patients infected w/ hepatitis B or C for clinical & laboratory signs of active HBV or HCV infected. Active serious digestive system disease, hereditary deficiency of HGPRT. Signs of bone marrow depression. Regularly perform complete blood count for monitoring neutropenia. Not to be initiated until -ve pregnancy test has been obtained. Avoid use of live attenuated vaccines.
Live vaccines; concomitant use of cholestyramine & other drugs that interfere w/ enterohepatic circulation; aciclovir, ganciclovir, antacids containing Mg & Al hydroxides & OCs; azathioprine; tacrolimus.
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