Novell Pharma


Averroes Pharma
Concise Prescribing Info
Norepinephrine bitartrate
BP control in certain acute hypotensive states eg, pheochromocytomectomy, sympathectomy, poliomyelitis, spinal anaesth, MI, septicemia, blood transfusion, drug reactions. Adjunct in cardiac arrest & profound hypotension.
Dosage/Direction for Use
Initially 2-3 mL/min IV infusion. Maintenance: 0.5-1 mL/min. Duration: Up to 6 days.
Hypersensitivity to noradrenaline tartrate or NaCl, Na metabisulfite, citric acid monohydrate, Na citrate dihydrate. Patients hypotensive from blood vol deficits; mesenteric or peripheral vascular thrombosis; profound hypoxia or hypercarbia. Concomitant use w/ cyclopropane & halothane anaesth.
Special Precautions
Sulfite sensitivity. Occlusive vascular diseases eg, atherosclerosis, arteriosclerosis, diabetic endarteritis, Buerger's disease. Monitor BP & rate of flow frequently to avoid HTN. Avoid catheter tie-in technique; extravasation into tissues. Concomitant use w/ MAOIs, triptyline- or imipramine-type antidepressants. Pregnancy & lactation. Paed patients. Not to be administered into leg veins of elderly.
Adverse Reactions
Anxiety; headache; arrhythmia, bradycardia, stress cardiomyopathy; HTN, peripheral ischaemia including gangrene, plasma vol depletion; dyspnoea; inj site extravasation & necrosis.
Drug Interactions
Severe, prolonged HTN & possible arrhythmia w/ volatile halogenated anaesth, MAOIs, linezolid, TCAs, adrenergic serotoninergic drugs or other cardiac sensitizing agents.
MIMS Class
ATC Classification
C01CA03 - norepinephrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.
N-Epi infusion conc 1 mg/mL
4 mL x 5 × 1's
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