Generic Medicine Info
Indications and Dosage
Acute migraine attacks
Adult: Initially, 1-2.5 mg, dose may be repeated after 4 hr if symptoms recur (2nd dose should not be taken for same attack). Max: 5 mg daily.
Renal Impairment
Mild to moderate: Initially, 1 mg. Max 2.5 mg daily.
CrCl (mL/min)  Dosage
 <15  Contraindicated.
Hepatic Impairment
Mild to moderate (Child-Pugh class A or B): Initially, 1 mg. Max 2.5 mg daily. Severe (Child-Pugh class C): Contraindicated.
May be taken with or without food.
Hypersensitivity. Coronary artery disease (e.g. angina pectoris, silent ischaemia, MI), coronary artery vasospasm, Prinzmetal’s angina, uncontrolled HTN, cerebrovascular syndromes (e.g. stroke, TIA), hemiplegic or basilar migraine, Wolff-Parkinson-White syndrome, peripheral vascular disease, ischemic bowel disease. Severe renal (CrCl <15 mL/min) and hepatic (Child-Pugh class C) impairment. Concomitant use w/ ergot derivatives and 5-HT1 receptor agonists.
Special Precautions
Patient w/ multiple CV risk factors. Not intended for cluster headache and for the prevention of migraine attacks. Mild to moderate renal and hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Significant: Chest pain/tightness, peripheral vascular ischaemia, GI vascular ischaemia/infarction, splenic infarction, Raynauld’s syndrome, transient and permanent blindness, partial loss of vision, recurrent/rebound headaches, withdrawal syndrome; hypertensive crisis, medication-overuse headache (MOH).
Nervous: Tingling sensation, paraesthesia, dizziness, somnolence, drowsiness, malaise, fatigue, heaviness sensation, hot/cold flushes, dizziness, vertigo, weakness.
CV: Bradycardia, palpitations.
GI: Nausea, vomiting, xerostomia.
Resp: Pharynx constriction.
Musculoskeletal: Neck pain, myalgia.
Ophthalmologic: Photophobia.
Potentially Fatal: Acute MI, coronary artery vasospasm, transient ischaemia, ventricular tachycardia/fibrillation, cerebral or subarachnoid haemorrhage, stroke, hypersensitivity reactions (e.g. angioedema).
Patient Counseling Information
This drug may cause dizziness, weakness, or drowsiness, if affected, do not drive or operate machinery.
Monitoring Parameters
Assess clear diagnosis of migraine and neurological conditions prior to initiation of therapy. Perform periodic CV evaluation for patients w/ risk factors for coronary artery disease who are receiving intermittent long-term therapy. Monitor ECG, BP, signs and symptoms of withdrawal, serotonin syndrome, angina, hypersensitivity reactions, and headache severity.
Symptoms: Increase in BP, light-headedness, neck tension, tiredness, loss of coordination, ECG changes. Management: Supportive treatment. Monitor patient for at least 24 hr.
Drug Interactions
Potentially Fatal: May cause additive vasospastic reactions w/ ergot derivatives and 5-HT1 receptor agonists. Risk of serotonin syndrome w/ SSRIs or serotonin norepinephrine reuptake inhibitors (SNRIs).
Food Interaction
May cause undesirable adverse effects w/ St John’s wort.
Description: Naratriptan is a selective serotonin (5-HT1B/1D) agonist in intracranial blood vessels, which causes vasoconstriction and reduction in oedema formation in the meninges thus alleviating migraine. It is also thought to inhibit trigeminal nerve activity.
Absorption: Rapidly and well absorbed from the GI tract. Bioavailability: Approx 70%. Time to peak plasma concentration: 2-3 hr.
Distribution: Volume of distribution: 170 L. Plasma protein binding: Approx 29%.
Metabolism: Metabolised in the liver by CYP enzymes into inactive metabolites.
Excretion: Via urine (50% as unchanged drug, 30% as inactive metabolites). Elimination half-life: 6 hr.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Naratriptan, CID=4440, (accessed on Jan. 22, 2020)

Store between 20-25°C.
MIMS Class
Antimigraine Preparations
ATC Classification
N02CC02 - naratriptan ; Belongs to the class of selective serotonin (5HT1) agonists preparations. Used to relieve migraine.
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Anon. Naratriptan. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 24/08/2017.

Buckingham R (ed). Naratriptan Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 24/08/2017.

Joint Formulary Committee. Naratriptan. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 24/08/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Naratriptan Hydrochloride. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). Accessed 24/08/2017.

Disclaimer: This information is independently developed by MIMS based on Naratriptan from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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