Niclosamide


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Pork tapeworm infestation 2 g as a single dose after a light breakfast. Beef or fish tapeworm infections 1 g after breakfast and 1 g an hr later. Dwarf-tapeworm infections Initial: 2 g on the 1st day followed by 1 g/day for 6 days.
Dosage Details
Oral
Pork tapeworm infestation
Adult: 2 g as a single dose after a light breakfast.
Child: <2 yr: 500 mg; 2-6 yr: 1 g. All doses to be taken as a single dose after a light breakfast.

Oral
Dwarf-tapeworm infections
Adult: Initially, 2 g on the 1st day followed by 1 g daily for 6 days.
Child: <2 yr: 500 mg on the 1st day followed by 250 mg daily for 6 days; 2-6 yr: 1 g on the 1st day followed by 500 mg daily for 6 days.

Oral
Beef or fish tapeworm infections
Adult: 1 g after breakfast and 1 g an hr later.
Child: <2 yr: 250 mg after breakfast and 250 mg an hr later; 2-6 yr: 500 mg after breakfast and 500 mg an hr later.
Administration
Should be taken with food.
Contraindications
Hypersensitivity.
Adverse Reactions
GI disturbances (e.g. nausea, retching, abdominal pain), lightheadedness, pruritus.
Drug Interactions
Possible increase in adverse effects with alcohol.
Action
Description: Niclosamide is active against intestinal tapeworms. It inhibits oxidative phosphorylation in mitochondria of the worms resulting in energy depletion.
Pharmacokinetics:
Absorption: Insignificantly absorbed from the GI tract (oral).
Storage
Store below 25°C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Niclosamide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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