atracurium besilate


Novell Pharma


Averroes Pharma
Concise Prescribing Info
Atracurium besylate
Adjunct to general anesth to enable tracheal intubations & to relax skeletal muscles during surgery or controlled ventilation; to facilitate mechanical ventilation in ICU patients.
Dosage/Direction for Use
Adult 0.3-0.6 mg/kg IV inj depending on duration of full block required or 0.3-0.6 mg/kg initial bolus dose, maintained as continuous infusion at rates 0.3-0.6 mg/kg/hr. Endotracheal intubation: 0.5-0.6 mg/kg IV inj. Childn >1 mth Adult dose. CV disease patient Initial dose should be administered over 60 sec. ICU patient Optional initial bolus dose 0.3-0.6 mg/kg, maintained as continuous infusion at rates between 0.65-0.78 mg/kg/hr.
Special Precautions
History of hypersensitivity to effects of histamine. Myasthenia gravis, other forms of neuromuscular disease & severe electrolyte imbalance, hypovolaemic, burn patients. Pregnancy & lactation.
Adverse Reactions
Skin flushing, mild transient hypotension or bronchospasm.
Drug Interactions
Increased neuromuscular blockade by inhalation anesth eg, halothane, isoflurane, enflurane. Increased magnitude &/or duration of nondepolarizing neuromuscular blockade w/ aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin, clindamycin; propranolol, Ca-channel blockers, lignocaine, procainamide, quinidine; furosemide, mannitol, thiazide diuretics, acetazolamide; Mg sulfate, ketamine, lithium salts; trimetaphan, hexamethonium. May aggravate or unmask latent myasthenia gravis w/ β-blockers, antiarrhythmics, antirheumatics, trimetaphan, chlorpromazine, steroids, phenytoin, lithium. Lengthened onset & shortened duration of nondepolarizing neuromuscular block by chronic anticonvulsant therapy.
ATC Classification
M03AC04 - atracurium ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
Notrixum soln for inj (amp) 10 mg/mL
2.5 mL x 5 × 1's;5 mL x 5 × 1's
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