Not recommended in primary aldosteronism. Intravascular vol depletion, other conditions w/ renin-angiotensin-aldosterone system stimulation, renovascular HTN, hyperkalaemia, dual blockade of renin-angiotensin-aldosterone system, diabetic nephropathy, aortic/mitral valve stenosis, obstructive hypertrophic cardiomyopathy, sprue-like enteropathy, excessive decreased BP in patients w/ ischemic heart or cerebrovascular disease. Ethnic differences. Not recommended in concomitant use w/ lithium. Concomitant use w/ ACE inhibitors, K supplements, K-containing salt substitutes, K-sparing diuretics, NSAIDs including COX-2 inhibitors, heparin, ciclosporin, tacrolimus, trimethoprim. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Kidney transplantation or end-stage renal disease. Mild to moderate renal & moderate hepatic impairment. Not recommended in severe renal & hepatic impairment. Not to be initiated during 1st trimester of pregnancy. Not recommended during lactation. Childn & adolescents <18 yr. Not to be used in childn <1 yr.