Novell Pharma


Averroes Pharma
Concise Prescribing Info
Management of cytotoxic chemo- & radiotherapy induced nausea & vomiting (CINV & RINV). Prevention & treatment of post-op nausea & vomiting (PONV).
Dosage/Direction for Use
Recommended dose: 8 mg bd. Adult CINV & RINV 8 mg 1-2 hr prior to chemo- or radiotherapy, followed by 8 mg every 12 hr for max: 5 days. Highly emetogenic chemotherapy Single dose up to 24 mg w/ oral dexamethasone Na phosphate 12 mg 1-2 hr prior to chemotherapy. CINV Childn & adolescent 3-17 yr Commence oral dosing 12 hr after IV dose. >1.2 m2 IV dose + 8 mg PO after 12 hr on day 1, continue w/ 8 mg PO every 12 hr for days 2-6; ≥0.6 to ≤1.2 m2 IV dose + 4 mg PO after 12 hr on day 1, continue w/ 4 mg PO every 12 hr for days 2-6; >10 kg: IV dose on day 1, continue w/ 4 mg PO every 12 hr on days 2-6. Adult PONV 16 mg 1 hr prior anaesth.
May be taken with or without food.
Hypersensitivity. Concomitant use w/ apomorphine.
Special Precautions
Hypersensitivity to other selective 5-HT3 receptor antagonists. Monitor signs of subacute intestinal obstruction. Moderate or severe hepatic impairment. Not recommended during pregnancy & lactation.
Adverse Reactions
Headache, sensation of warmth or flushing, hiccups.
Drug Interactions
Increased oral clearance & decreased blood conc w/ potent CYP3A4 inducers eg, phenytoin, carbamazepine & rifampicin. Reduced analgesic effect of tramadol.
MIMS Class
ATC Classification
A04AA01 - ondansetron ; Belongs to the class of serotonin (5HT3) antagonists. Used for the prevention of nausea and vomiting.
Ondavell FC tab 4 mg
2 × 6's
Ondavell FC tab 8 mg
2 × 6's
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