Clomifene citrate is indicated for the treatment of ovulatory failure.
Clomifene citrate is indicated only for patients in whom ovulatory dysfunction is demonstrated, who meet the conditions described in this prescribing information and for whom Clomifene is not contraindicated.
Other causes of infertility must be excluded or adequately treated before giving Clomifene citrate. Good levels of endogenous estrogen (as estimated from vaginal smears, endometrial biopsy, assay of urinary estrogen or endometrial bleeding in response to progesterone) provide a favorable prognosis for ovulatory response induced by Clomifene citrate. A low level of estrogen although clinically less favorable does not preclude successful outcome of therapy.
Clomifene Citrate therapy is ineffective in patients with primary pituitary or primary ovarian failure. Clomifene citrate therapy cannot be expected to substitute for specific treatment of other causes of ovulatory failure, such as thyroid or adrenal disorders.