Discontinue use at 1st appearance of skin rash, mucosal lesions or any other signs of hypersensitivity & if abnormal liver tests persist or worsen, if clinical signs & symptoms consistent w/ liver disease develops or systemic manifestations occur. Increased risk of serious CV thrombotic events, MI & stroke. Patients w/ prior history of or active GI disease eg, ulceration, bleeding or inflammation or other risk factors associated w/ PUD eg, alcoholism, smoking & corticosteroid therapy; HTN, compromised cardiac function & other conditions predisposing to, or worsened by fluid retention; preexisting CHF; liver cirrhosis, nephrotic syndrome, overt renal disease. Serious skin reactions eg, exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis. Avoid concomitant use w/ non-aspirin NSAIDs including COX-2 inhibitors, oral anticoagulants. False +ve reaction for urinary bile using diazo tab test. Not to be administered in renal impairment. Avoid use during 3rd trimester of pregnancy. Not recommended during pregnancy. Not to be used during lactation. Elderly or debilitated patients.