RespulesBronchial asthmaAdult Initially 1-2 mg bd. Maintenance: 0.5-1 mg bd. Childn Initially 0.5-1 mg bd. Maintenance: 0.25-0.5 mg bd. CroupInfant & childn 2 mg as single dose or 2 1-mg dose separated by 30 min, every 12 hr up to 36 hr or until improvement. TurbuhalerAdult 200-800 mcg daily in 2-4 divided inhalations. Severe cases Up to 1,600 mcg. Childn ≥7 yr 100-800 mcg daily in 2-4 divided doses, 5-7 yr 100-400 mcg daily in 2-4 divided doses.
Not indicated for rapid relief of bronchospasm. Not suitable as sole therapy for status asthmaticus or other acute asthma exacerbations. Active or quiescent pulmonary TB or fungal, bacterial or viral airway infections. Pneumonia in patients w/ COPD. HPA axis suppression & adrenal insufficiency, bone density reduction, cataract, glaucoma. Periods of stress, severe asthma attack or elective surgery. High dose & prolonged use. Concomitant use w/ CYP3A4-metabolised drugs. Hepatic impairment. Pregnancy & lactation. Growth retardation in childn & adolescents. Respules: Not to be used w/ positive pressure delivering systems. Turbuhaler: Oral candidiasis. Paradoxical bronchospasm. Avoid concomitant use w/ HIV PIs.
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