Essential Mild HTN
Initially 10 mg daily. Other degrees of HTN
Initially 20 mg daily. Maintenance: 20 mg once daily. Max: 40 mg daily. Renovascular HTN
Initiate w/ lower starting dose (eg, ≤5 mg) & adjust accordingly to patient's needs. Mild renal impairment (CrCl >30 to <80 mL/min)
Initially 5-10 mg daily. Moderate renal impairment (CrCl >10 to ≤30 mL/min)
Initially 2.5-5 mg daily. Severe renal impairment (CrCl ≤10 mL/min)
Initially 2.5 mg daily on dialysis days, adjusted depending on BP response on nondialysis days. Heart failure/asymptomatic left ventricular dysfunction
Initially 2.5 mg administered under close medical supervision to determine initial effect on BP, may be increased gradually to 20 mg in single or 2 divided doses as maintenance over 2-4 wk period.