Solu-Cortef

Solu-Cortef

hydrocortisone

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Hydrocortisone Na succinate
Indications/Uses
In situations requiring rapid & intense hormonal effect eg, acute adrenocortical insufficiency, bilateral adrenalectomy, severe shock, acute hypersensitivity reactions, overwhelming infections w/ severe toxicity, SLE in relapse, aspiration pneumonitis.
Dosage/Direction for Use
Adult Initially 100-500 mg IV over 30 sec to 10 min. Dose may be repeated at 2-, 4- or 6-hr intervals. Ped patient Initially 0.56-8 mg/kg daily in 3 or 4 divided doses (20-240 mg/m2 daily).
Contraindications
Hypersensitivity. Systemic fungal infection, idiopathic thrombocytopenic purpura. Intrathecal administration.
Special Precautions
Avoid deltoid muscle inj. Not for treatment of traumatic brain injury. Not to be used IA, intrabursally or for intratendinous & epidural administration for local effect. Not to be used in cerebral malaria & active ocular herpes simplex. Discontinue use in Kaposi's sarcoma patients. Corticosteroid effects. Recent MI. Susceptibility to infections. Exacerbated systemic fungal & intercurrent infections. Known or suspected Strongyloides (threadworm) infestation. Active or latent TB, posterior subcapsular cataracts, glaucoma. CHF, HTN, active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses & non-specific ulcerative colitis, osteoporosis, myasthenia gravis. Aggravated existing emotional instability or psychotic tendencies. Pheochromocytoma. Not recommended in optic neuritis. Dietary salt restriction & K supplementation. Not to be used w/ live or live, attenuated vaccine. Monitor IOP in therapy >6 wk. Avoid abrupt w/drawal. Avoid exposure to chicken pox or measles. May affect ability to drive & use machines. Renal insufficiency; cirrhosis. Pregnancy & lactation. Elderly.
Adverse Reactions
Allergic reactions; leukocytosis; CV, dermatologic, endocrinal, GI, ophth reactions; fluid & electrolyte disturbances; -ve nitrogen balance; musculoskeletal, neurologic/psychiatric disorders.
Drug Interactions
Loss of corticosteroid-induced adrenal suppression w/ aminoglutethimide. Development of hypokalemia w/ K-depleting agents. Decreased clearance w/ macrolide antibiotics. Severe weakness in myasthenia gravis patients w/ anticholinesterases. Inhibition of response to warfarin. Increased blood glucose conc by antidiabetics. Decreased INH serum conc. Increased clearance by cholestyramine. Increased activity of both cyclosporine & corticosteroids. Increased risk of arrhythmias due to hypokalemia w/ digitalis glycosides. Decreased hepatic metabolism w/ estrogens eg, OCs. Enhanced metabolism by hepatic enzyme inducers eg, barbiturates, phenytoin, carbamazepine, rifampin. Increased plasma conc w/ hepatic enzyme inhibitors. Increased salicylate clearance.
MIMS Class
Corticosteroid Hormones
ATC Classification
H02AB09 - hydrocortisone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
Presentation/Packing
Form
Solu-Cortef inj 100 mg/2 mL
Packing/Price
1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in