Stripole

Stripole

pantoprazole

Manufacturer:

Gufic Lifesciences

Distributor:

Averroes Pharma
Concise Prescribing Info
Contents
Pantoprazole Na sesquihydrate
Indications/Uses
Short-term use for symptomatic improvement & healing of duodenal & gastric ulcer, moderate & severe reflux oesophagitis, Zollinger-Ellison syndrome & other pathological hypersecretory conditions.
Dosage/Direction for Use
Gastric & duodenal ulcer, moderate & severe reflux esophagitis 40 mg IV daily. Long-term management of Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg IV daily, may be titrated up or down as needed. Doses >80 mg IV daily to be given bd. Rapid acid control Initially 2 x 80 mg IV. Severe hepatic impairment Not to exceed 20 mg IV daily.
Contraindications
Hypersensitivity to pantoprazole or substituted benzimidazoles.
Special Precautions
Exclude malignancy in the presence of alarm symptom eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena. Increased risk of GI infections caused by bacteria eg, Salmonella, Campylobacter; hip, wrist & spine fracture; Clostridium difficile-associated diarrhea. Severe hypomagnesaemia; subacute cutaneous lupus erythematosus; vit B12 deficiency. Interference w/ chromogranin A levels. Ensure adequate intake of vit D & Ca. Long-term & high-dose use. May affect ability to drive & use machines. Not recommended to be co-administered w/ atazanavir. Concomitant use w/ digoxin or drugs causing hypomagnesaemia eg, diuretics. Severe hepatic impairment. Not to be used during pregnancy. Lactation.
Adverse Reactions
Diarrhea; headache; benign fundic gland polyps; inj site thrombophlebitis.
Drug Interactions
Reduced absorption of drugs w/ gastric pH dependent bioavailability eg, some azole antifungals (eg, ketoconazole, itraconazole, posaconazole), erlotinib. Substantial reduction in bioavailability of HIV medications. Monitor prothrombin time/INR w/ coumarin anticoagulants eg, phenprocoumon or warfarin. Increased systemic exposure w/ CYP2C19 inhibitors eg, fluvoxamine. Reduced plasma conc w/ CYP2C19 & CYP3A4 inducers eg, rifampicin, St. John's wort (Hypericum perforatum). Increased methotrexate levels.
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Stripole powd for inj 40 mg
Packing/Price
1's
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