Exclude malignancy in the presence of alarm symptom eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena. Increased risk of GI infections caused by bacteria eg, Salmonella, Campylobacter; hip, wrist & spine fracture; Clostridium difficile
-associated diarrhea. Severe hypomagnesaemia; subacute cutaneous lupus erythematosus; vit B12
deficiency. Interference w/ chromogranin A levels. Ensure adequate intake of vit D & Ca. Long-term & high-dose use. May affect ability to drive & use machines. Not recommended to be co-administered w/ atazanavir. Concomitant use w/ digoxin or drugs causing hypomagnesaemia eg, diuretics. Severe hepatic impairment. Not to be used during pregnancy. Lactation.