Stripole Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Pantoprazole Na sesquihydrate

Indications/Uses

Short-term use for symptomatic improvement & healing of duodenal & gastric ulcer, moderate & severe reflux oesophagitis, Zollinger-Ellison syndrome & other pathological hypersecretory conditions.

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Dosage/Direction for Use

Gastric & duodenal ulcer, moderate & severe reflux esophagitis 40 mg IV daily. Long-term management of Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg IV daily, may be titrated up or down as needed. Doses >80 mg IV daily to be given bd. Rapid acid control Initially 2 x 80 mg IV. Severe hepatic impairment Not to exceed 20 mg IV daily.

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Overdosage

View Stripole overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity to pantoprazole or substituted benzimidazoles.

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Special Precautions

Exclude malignancy in the presence of alarming symptom eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena. Increased risk of GI infections caused by bacteria eg, Salmonella, Campylobacter; hip, wrist & spine fracture; Clostridium difficile-associated diarrhea. Severe hypomagnesaemia; subacute cutaneous lupus erythematosus; vit B₁₂ deficiency. Interference w/ chromogranin A levels. Ensure adequate intake of vit D & Ca. Long-term & high-dose use. May affect ability to drive & use machines. Not recommended to be co-administered w/ atazanavir. Concomitant use w/ digoxin or drugs causing hypomagnesaemia eg, diuretics. Severe hepatic impairment. Not to be used during pregnancy. Lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Diarrhea; headache; benign fundic gland polyps; inj site thrombophlebitis.

Drug Interactions

Reduced absorption of drugs w/ gastric pH dependent bioavailability eg, some azole antifungals (eg, ketoconazole, itraconazole, posaconazole), erlotinib. Substantial reduction in bioavailability of HIV medications. Monitor prothrombin time/INR w/ coumarin anticoagulants eg, phenprocoumon or warfarin. Increased systemic exposure w/ CYP2C19 inhibitors eg, fluvoxamine. Reduced plasma conc w/ CYP2C19 & CYP3A4 inducers eg, rifampicin, St. John's wort (Hypericum perforatum). Increased MTX levels.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Stripole detailed prescribing information

Storage

View Stripole storage conditions for details to ensure optimal shelf-life.

Description

View Stripole description for details of the chemical structure and excipients (inactive components).

Action

View Stripole mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Regulatory Classification

Presentation/Packing

Form

Stripole powd for inj 40 mg

Packing/Price

1's

Stripole

pantoprazole

Manufacturer:

Gufic Lifesciences

Distributor:

Averroes Pharma