Terconazole: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Vaginal
Vulvovaginal candidiasis

Adult: As 0.4 or 0.8% cream: Apply intravaginally at bedtime for 7 consecutive days or for 3 consecutive days, respectively. As 80 mg supp: Admin intravaginally at bedtime for 3 consecutive days.

Contraindications

Hypersensitivity.

Special Precautions

Discontinue if irritation, sensitisation, fever, chills or flu-like symptoms develop. Pregnancy and lactation.

Adverse Reactions

Anaphylaxis, toxic epidermal necrolysis. Vulvovaginal burning, pruritus, irritation, itching; headache, dysmenorrhoea; genital, body and abdominal pain; flu-like syndrome (e.g. fever, chills, hypotension), vertigo, nausea.

Pregnancy Category (US FDA)

Topical/Vag: C

Patient Counseling Information

May damage rubber or latex condoms or diaphragms, avoid use while on treatment.

Action

Description: Terconazole disrupts ergosterol synthesis by binding to fungal cytochrome P450. It is active in vitro against Candida spp. and other fungi. It has some antibacterial activity in vitro but not against usual vag flora e.g. lactobacilli.
Pharmacokinetics:
Absorption: Absorbed systemically (5-16%).
Metabolism: Metabolised hepatically.
Excretion: Via urine and faeces.

Chemical Structure

Storage

Store between 15-30°C.

MIMS Class

Preparations for Vaginal Conditions

References

Anon. Terconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/07/2014.

Buckingham R (ed). Terconazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Terconazole (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 21/07/2014.

Terazol 7 Cream, Terazol 3 Cream, Terazol 3 Suppository (Janssen Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/07/2014.

Terazol Crème and Suppositories. U.S. FDA. https://www.fda.gov/. Accessed 21/07/2014.

Wickersham RM. Terconazole-Vaginal. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 21/07/2014.

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