Terconazole


Concise Prescribing Info
Indications/Uses
Vulvovaginal candidiasis.
Dosage/Direction for Use
Adult : Vag As 0.4 or 0.8% cream: Apply intravaginally at bedtime for 7 or 3 consecutive days, respectively. As 80 mg supp: Admin intravaginally at bedtime for 3 consecutive days.
Dosage Details
Vaginal
Vulvovaginal candidiasis
Adult: As 0.4 or 0.8% cream: Apply intravaginally at bedtime for 7 consecutive days or for 3 consecutive days, respectively. As 80 mg supp: Admin intravaginally at bedtime for 3 consecutive days.
Contraindications
Hypersensitivity.
Special Precautions
Discontinue if irritation, sensitisation, fever, chills or flu-like symptoms develop. Pregnancy and lactation.
Adverse Reactions
Anaphylaxis, toxic epidermal necrolysis. Vulvovaginal burning, pruritus, irritation, itching; headache, dysmenorrhoea; genital, body and abdominal pain; flu-like syndrome (e.g. fever, chills, hypotension), vertigo, nausea.
Patient Counseling Information
May damage rubber or latex condoms or diaphragms, avoid use while on treatment.
Action
Description: Terconazole disrupts ergosterol synthesis by binding to fungal cytochrome P450. It is active in vitro against Candida spp. and other fungi. It has some antibacterial activity in vitro but not against usual vag flora e.g. lactobacilli.
Pharmacokinetics:
Absorption: Absorbed systemically (5-16%).
Metabolism: Metabolised hepatically.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image
Terconazole

Source: National Center for Biotechnology Information. PubChem Database. Terconazole, CID=441383, https://pubchem.ncbi.nlm.nih.gov/compound/Terconazole (accessed on Jan. 23, 2020)

Storage
Store between 15-30°C.
References
Anon. Terconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/07/2014.

Buckingham R (ed). Terconazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Terconazole (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 21/07/2014.

Terazol 7 Cream, Terazol 3 Cream, Terazol 3 Suppository (Janssen Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/07/2014.

Terazol Crème and Suppositories. U.S. FDA. https://www.fda.gov/. Accessed 21/07/2014.

Wickersham RM. Terconazole-Vaginal. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 21/07/2014.

Disclaimer: This information is independently developed by MIMS based on Terconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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