Generic Medicine Info
Indications and Dosage
Nail fungal infections
Adult: As 28% soln: Apply to the affected nails and immediately surrounding skin 12 hrly for up to 6-12 mth.
Child: Same as adult dose.
Elderly: Same as adult dose.

Vaginal candidiasis
Adult: As 6.5% oint: Insert 1 applicatorful intravaginally at bedtime as single dose.
Special Precautions
Self-medication in patient w/ DM, HIV infection. Girls <12 yr (vag). Pregnancy and lactation.
Adverse Reactions
Vulvovaginal burning and irritation, vaginitis, pruritus, vulvovaginal disorder and desquamation, vag pain, vulvar oedema or swelling, vag discharge, vag dryness, rash and dyspareunia; headache, abdominal pain, dysuria, nocturia, pharyngitis, rhinitis; transient, minor increases in LDH, AST (SGOT) and ALT (SGPT). Contact dermatitis, burning, irritation (topical).
Patient Counseling Information
Vag: Avoid sexual intercourse. Condoms and diaphragms may be damaged and fail to prevent pregnancy or STD, may resume usage 3 days after treatment. Avoid using tampons, douches, spermicides or other vag products.
Description: Tioconazole, a synthetic azole antifungal, interferes w/ synthesis of ergosterol which is needed for fungal cell membrane synthesis.
Onset: Intravaginal: Some improvement w/in 24 hr; complete relief w/in 7 days.
Absorption: Intravaginal: Absorbed systemically (small amounts).
Distribution: Persists in vag fluid for 24-72 hr.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Tioconazole, CID=5482, https://pubchem.ncbi.nlm.nih.gov/compound/Tioconazole (accessed on Jan. 23, 2020)

Store between 20-25°C.
MIMS Class
Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites
Anon. Tioconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/07/2014.

Buckingham R (ed). Tioconazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/08/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Tioconazole (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 18/07/2014.

Tioconazole 1-1 Dose Treatment Ointment (Rite Aid Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 18/07/2014.

Wickersham RM. Tioconazole – Vaginal. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 18/07/2014.

Disclaimer: This information is independently developed by MIMS based on Tioconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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