Tioconazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Vag Vag candidiasis As 6.5% oint: Insert 1 applicatorful intravaginally at bedtime as single dose. Topical Nail fungal infections As 28% soln: Apply to affected nails and immediately surrounding skin 12 hrly for up to 6-12 mth.
Dosage Details
Topical/Cutaneous
Nail fungal infections
Adult: As 28% soln: Apply to the affected nails and immediately surrounding skin 12 hrly for up to 6-12 mth.
Child: Same as adult dose.
Elderly: Same as adult dose.

Vaginal
Vaginal candidiasis
Adult: As 6.5% oint: Insert 1 applicatorful intravaginally at bedtime as single dose.
Contraindications
Hypersensitivity.
Special Precautions
Self-medication in patient w/ DM, HIV infection. Girls <12 yr (vag). Pregnancy and lactation.
Adverse Reactions
Vulvovaginal burning and irritation, vaginitis, pruritus, vulvovaginal disorder and desquamation, vag pain, vulvar oedema or swelling, vag discharge, vag dryness, rash and dyspareunia; headache, abdominal pain, dysuria, nocturia, pharyngitis, rhinitis; transient, minor increases in LDH, AST (SGOT) and ALT (SGPT). Contact dermatitis, burning, irritation (topical).
Patient Counseling Information
Vag: Avoid sexual intercourse. Condoms and diaphragms may be damaged and fail to prevent pregnancy or STD, may resume usage 3 days after treatment. Avoid using tampons, douches, spermicides or other vag products.
Action
Description: Tioconazole, a synthetic azole antifungal, interferes w/ synthesis of ergosterol which is needed for fungal cell membrane synthesis.
Onset: Intravaginal: Some improvement w/in 24 hr; complete relief w/in 7 days.
Pharmacokinetics:
Absorption: Intravaginal: Absorbed systemically (small amounts).
Distribution: Persists in vag fluid for 24-72 hr.
Excretion: Via urine and faeces.
Chemical Structure

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Storage
Store between 20-25°C.
Disclaimer: This information is independently developed by MIMS based on Tioconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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