Adjunctive therapy epilepsy Adult Initially 25-50 mg nightly for 1 wk. Subsequently at wkly or bi-wkly intervals, increase dose to 25-50 (to 100) mg daily in 2 divided doses.
Childn ≥2 yr Approx 5-9 mg/kg daily in 2 divided doses. Titrate at ≤25 mg (based on range of 1-3 mg/kg daily) nightly for the 1st wk. Subsequently at 1 or 2 wkly intervals, w/ increments of 1-3 mg/kg daily in 2 divided doses.
Monotherapy epilepsy Adult Titrate at 25 mg nightly for 1 wk. Subsequently at 1 or 2 wkly intervals, increase dose by increments of 25 or 50 mg daily in 2 divided doses. Initial target dose: 100 mg daily. Max: 500 mg.
Childn ≥2 yr Initially at 0.5-1 mg/kg daily nightly for the 1st wk. Subsequently at 1 or 2 wkly intervals, increase dose by increments of 0.5-1 mg/kg daily in 2 divided doses. Initial target dose: 3-6 mg/kg daily.
Prophylaxis of migraine Initially 25 mg nightly for 1 wk, then increased at 25 mg daily increments at 1-wk intervals. Recommended total daily dose: 100 mg in 2 divided doses.
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