insulin glargine




Concise Prescribing Info
Insulin glargine
Dosage/Direction for Use
Individualized dosage. Type 1 DM Once daily w/ short-/rapid-acting insulin & requires individual dose adjustments. Type 2 DM Initially 0.2 units/kg followed by individual dose adjustments, may be given w/ other antihyperglycaemic products.
Special Precautions
Not to be administered IV, not to be used in insulin infusion pumps. Not for diabetic ketoacidosis. Patients w/ significant coronary arteries stenoses or blood vessels supplying the brain (risk of cardiac or cerebral complications of hypoglycaemia), proliferative retinopathy; patients in whom glycaemic control is markedly improved, whom hypoglycaemia develops gradually & whom an autonomic neuropathy is present, after transfer from animal insulin to human insulin, long history of diabetes, suffering from a psychiatric illness, receiving concurrent treatment w/certain other medicinal products; change in the inj area, improved insulin sensitivity (eg, removal of stress factors), unaccustomed, increased or prolonged physical activity, intercurrent illness (eg, vomiting, diarrhoea), inadequate food intake, missed meals, alcohol consumption, certain uncompensated endocrine disorders (eg, hypothyroidism & anterior pituitary or adrenocortical insufficiency); switching between & from other insulins. Combination w/ pioglitazone. May affect ability to drive & use machines. Lactation. Childn <18 yr. Elderly.
Adverse Reactions
Hypoglycaemia. Lipohypertrophy; inj site reactions ie, redness, pain, itching, hives, swelling, inflammation.
Drug Interactions
Enhanced blood-glucose-lowering effect w/ antihyperglycaemics, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates & sulfonamides. Reduced blood-glucose-lowering effect by corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, oestrogens & progestogens, phenothiazine derivatives, somatropin, sympathomimetic medicinal products [eg, epinephrine (adrenaline), salbutamol, terbutaline], thyroid hormones, atypical antipsychotics (eg, clozapine & olanzapine) & PIs. Potentiated or weakened blood-glucose-lowering effect w/ β-blockers, clonidine, lithium salts or alcohol. Hypoglycemia sometimes followed by hyperglycemia w/ pentamidine. Reduced or absent signs of adrenergic counterregulation w/ sympatholytics eg, guanethidine, reserpine.
ATC Classification
A10AE04 - insulin glargine ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes.
Toujeo soln for inj 300 units/mL
1.5 mL x 1's
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