atracurium besilate




Zuellig Pharma
Concise Prescribing Info
Atracurium besylate
Adjunct to general anaesth to enable tracheal intubation, to relax skeletal muscles during surgery or controlled ventilation & to facilitate mechanical ventilation in ICU patients.
Dosage/Direction for Use
Adult & childn >1 mth IV inj Intubation dose: 0.3-0.6 mg/kg. Supplementary dose: 0.1-0.2 mg/kg. IV infusion 0.3-0.6 mg/kg/hr.
Hypersensitive to atracurium, cisatracurium or benzenesulfonic acid.
Special Precautions
Hypersensitivity to other neuromuscular-blocking agents. Increased sensitivity to effects of histamine. Myasthenia gravis, other neuromuscular disease & severe electrolyte disorders. Hypovolaemic; CV disease; conditions predisposing to seizures; burn patients. Not to be administered into blood transfusion infusion line. Not to be mixed w/ thiopentone or any alkaline agent. May affect ability to drive & use machines. Pregnancy & lactation. Elderly.
Adverse Reactions
Drug Interactions
Increased effects by inhalation anaesth, aminoglycosides, polymyxin, spectinomycin, tetracycline, lincomycin, clindamycin, antiarrhythmics, diuretics, Mg sulfate, ketamine, lithium salts, ganglion-blocking drugs. Increased sensitivity w/ β-blockers, anti-rheumatic drugs, trimetaphan, chlorpromazine, steroids, phenytoin. Prolonged & complex block w/ suxamethonium Cl. Shortened duration & diminished magnitude w/ anticholinesterases.
MIMS Class
Neuromuscular Blocking Agents
ATC Classification
M03AC04 - atracurium ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
Tracrium soln for inj 10 mg/mL
2.5 mL x 5 × 1's (RM50.95/box);5 mL x 5 × 1's (RM115.45/box)
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