Possibility of permanent change in eye colour, periorbital &/or eyelid skin darkening; increase length, thickness, pigmentation &/or number of lashes. Aphakic patients, pseudophakic patients w/ torn posterior lens cap or anterior chamber lenses. Patients w/ active intraocular inflammation; known risk factors for cystoid macular oedema or iritis/uveitis. Concomitant use w/ prostaglandin F2a analogues. May affect ability to drive & use machines. Not recommended in childn <18 yr.