Increased BP-lowering effect by other antihypertensive agents. Potentiated hypotensive effects by baclofen, amifostine. Aggravated orthostatic hypotension by alcohol, barbiturates, narcotics or antidepressants. Reduced antihypertensive effect w/ systemic corticosteroids. Telmisartan: Increased median plasma digoxin trough conc. Increased AUC & Cmax
of ramipril & ramiprilat. Increased serum lithium conc & toxicity. Reduced antihypertensive effect w/ NSAIDs. Amlodipine: Increased BP-lowering effects w/ grapefruit & grapefruit juice. Increased risk of hypotension w/ strong or moderate CYP3A4 inhibitors eg, PIs, azole antifungals, erythromycin or clarithromycin, verapamil, diltiazem. Varied plasma conc w/ strong CYP3A4 inducers eg, rifampicin, Hypericum perforatum
. Increased tacrolimus blood levels. Increased trough conc of cyclosporine in renal transplant patients. Increased exposure of simvastatin, mTOR inhibitors.