Zuellig Pharma
Concise Prescribing Info
Valaciclovir HCl
Herpes zoster. Reduces duration & proportion of patients w/ zoster-associated pain, which includes acute & post-herpetic neuralgia. Herpes simplex skin & mucous membrane infection including initial & recurrent genital herpes. Suppression of recurrent herpes simplex infection. Reduces transmission of genital herpes as suppressive therapy.
Dosage/Direction for Use
Adult Herpes zoster 1,000 mg tds for 7 days. Immunocompetent & immunocompromised patient CrCl at least 50 mL/min 1 g tds, 30-49 mL/min 1 g bd, 10-29 mL/min 1 g once daily, <10 mL/min 500 mg once daily. Herpes simplex infections 500 mg bd for 3-5 days (for recurrent episodes) or 10 days (for initial episodes). Immunocompetent patient CrCl at least 30 mL/min 500 mg bd, <30 mL/min 500 mg once daily. Suppression of herpes simplex infection recurrence in immunocompetent patient 500 mg once daily. CrCl at least 30 mL/min 500 mg once daily, <30 mL/min 250 mg once daily. Immunocompromised patient 500 mg bd. CrCl at least 30 mL/min 500 mg bd, <30 mL/min 500 mg once daily. Reduction of transmission of genital herpes 500 mg once daily.
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Hypersensitivity to valaciclovir or aciclovir.
Special Precautions
Not for treatment of genital herpes. Ensure adequate hydration during therapy. Renal impairment. Hepatic impairment or liver disease. Pregnancy & lactation. Elderly.
Adverse Reactions
Drug Interactions
Increased AUC by cimetidine, probenecid, mycophenolate mofetil. Changes in renal function w/ cyclosporin & tacrolimus.
MIMS Class
ATC Classification
J05AB11 - valaciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Valtrex FC tab 500 mg
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