Vocinti

Vocinti

vonoprazan

Manufacturer:

Takeda

Distributor:

DKSH
Concise Prescribing Info
Contents
Vonoprazan
Indications/Uses
Gastric & duodenal ulcer; reflux esophagitis (erosive esophagitis). Maintenance treatment of reflux esophagitis (erosive esophagitis). Prevention of gastric or duodenal ulcer recurrence during NSAID administration. Adjunct to H pylori eradication associated w/ gastric & duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, stomach after endoscopic resection of early stage cancer or H pylori gastritis.
Dosage/Direction for Use
Adult Gastric ulcer 20 mg once daily up to 8 wk. Duodenal ulcer 20 mg once daily up to 6 wk. Reflux esophagitis (erosive esophagitis) 20 mg once daily up to 4 wk, may be continued up to 8 wk if insufficient. Maintenance of reflux esophagitis healing 10 mg once daily, may be increased to 20 mg once daily if inadequate. Prevention of gastric & duodenal ulcer recurrence during NSAID administration 10 mg once daily. Adjunct to H pylori eradication 20 mg bd for 7 days w/ combination of 2 antibiotics following local label recommendations.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Discontinue use in patients w/ evidence of hepatic function abnormalities, or if signs or symptoms suggestive of hepatic dysfunction develops. Does not preclude gastric malignancy. Clostridium difficile-associated diarrhea including pseudomembranous colitis. Bone fracture. Concomitant use w/ drugs for which absorption is dependent on acidic intragastric pH. Renal & hepatic impairment. Not to be used during pregnancy. Avoid use during lactation. Childn <18 yr. Elderly.
Adverse Reactions
Drug Interactions
Interfered w/ absorption of drugs whose bioavailability is pH-dependent eg, atazanavir, nelfinavir. Increased blood conc w/ strong CYP3A4 inhibitors eg, clarithromycin. Increased conc w/ clarithromycin & amoxicillin regimen.
ATC Classification
A02BC08 - vonoprazan ; Belongs to the class of potassium-competitive acid blocker. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Vocinti FC tab 10 mg
Packing/Price
30's
Form
Vocinti FC tab 20 mg
Packing/Price
30's
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