IV infusion CAP & cSSTI Adult & adolescent 12 to <18 yr, ≥33 kg 600 mg over 5-60 min every 12 hr.
CrCl >30 to ≤50 mL/min 400 mg over 5-60 min every 12 hr, ≥
15 to ≤30 mL/min 300 mg over 5-60 min every 12 hr,
ESRD including haemodialysis 200 mg over 5-60 min every 12 hr.
Adolescent 12 to <18 yr, <33 kg & childn ≥2 to <12 yr 12 mg/kg over 5-60 min every 8 hr. Max: 400 mg.
CrCl >30 to ≤50 mL/min 8 mg/kg to max: 300 mg over 5-60 min every 8 hr,
≥15 to ≤30 mL/min 6 mg/kg to max: 200 mg over 5-60 min every 8 hr.
Infant ≥2 mth to <2 yr 8 mg/kg over 5-60 min every 8 hr.
cSSTI confirmed or suspected to be caused by S. aureus w/ MIC=2 or 4 mg/L to ceftaroline Adult 600 mg over 120 min every 8 hr.
CrCl >30 to ≤50 mL/min 400 mg over 120 min every 8 hr,
≥15 to ≤30 mL/min 300 mg over 120 min every 8 hr,
ESRD including haemodialysis 200 mg over 120 min every 8 hr.
Adolescent & childn ≥2 yr to <18 yr 12 mg/kg over 120 min every 8 hr. Max: 600 mg.
CrCl >30 to ≤50 mL/min 10 mg/kg to max: 400 mg over 120 min every 8 hr,
≥15 to ≤30 mL/min 8 mg/kg to max: 300 mg over 120 min every 8 hr.
Infant ≥2 mth to <2 yr 10 mg/kg over 120 min every 8 hr.
Duration of treatment:
CAP 5-7 days.
cSSTI 5-14 days.
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