Zovirax

Zovirax

aciclovir

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Aciclovir
Indications/Uses
Herpes simplex & varicella zoster infection. Prophylaxis of herpes simplex infection in immunocompromised patients. Tab/susp: Suppression of recurrent herpes simplex infection in immunocompromised patients. Inj: Herpes simplex in neonates.
Dosage/Direction for Use
Tab/susp Adult Herpes simplex 200 mg 5 times daily at 4-hrly intervals (omit nighttime dose) for 5 days, may be doubled to 400 mg in severely immunocompromised patient or those w/ impaired gut absorption. Suppression of herpes simplex in immunocompetent patient 200 mg qds at approx 6-hrly intervals or 400 mg bd at approx 12-hrly intervals, may titrate dose to 200 mg bd or tds. Prophylaxis of herpes simplex infection in immunocompromised patient 200 mg qds at approx 6-hrly interval. Treatment & prophylaxis of herpes simplex infections in immunocompromised childn >2 yr Adult dose, <2 yr ½ adult dose. Renal impairment CrCl <10 mL/min 200 mg bd at approx 12-hrly intervals. Varicella & herpes zoster 800 mg 5 times daily at approx 4-hrly interval for 7 days. Childn ≥6 yr 800 mg qds for 5 days, 2 to <6 yr 400 mg qds for 5 days, <2 yr 200 mg qds for 5 days. Severe renal impairment CrCl <10 mL/min 800 mg bd at approx 12-hrly intervals. Moderate renal impairment CrCl 10-25 mL/min 800 mg tds at approx 8-hrly intervals. Inj Herpes simplex & varicella zoster Adult 5 mg/kg IV infusion every 8 hr. Infant & childn ≥3 mth 250 mg/m2 IV infusion every 8 hr. Herpes encephalitis, immunocompromised patient w/ varicella zoster infection Adult 10 mg/kg IV infusion every 8 hr. Infant & childn 500 mg/m2 IV infusion every 8 hr. Prophylaxis of herpes simplex in immunocompromised patient Adult dose. Known suspected neonatal herpes 20 mg/kg IV every 8 hr for 21 days (for disseminated & CNS disease) or 14 days (for disease limited to skin & mucous membranes).
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort. May be dispersed in at least 50 mL of water or swallowed whole w/ a little water. Ensure adequate hydration especially for patients on high doses.
Contraindications
Hypersensitivity to aciclovir or valaciclovir.
Special Precautions
Maintain adequate hydration. Renal impairment. Pregnancy & lactation. Elderly. Inj: High dose.
Adverse Reactions
Nausea, vomiting; pruritus, rashes (eg, photosensitivity). Tab/susp: Headache, dizziness; diarrhoea, abdominal pain; fatigue, fever. Inj: Phlebitis; reversible increased liver-related enzymes; urticaria; increased blood urea & creatinine.
Drug Interactions
Increased AUC & reduced renal clearance by probenecid & cimetidine. Increased plasma AUC of mycophenolate mofetil.
MIMS Class
ATC Classification
J05AB01 - aciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Zovirax dispersible tab 800 mg
Packing/Price
25's
Form
Zovirax dispersible tab 200 mg
Packing/Price
25's
Form
Zovirax powd for inj (vial) 250 mg
Packing/Price
5 × 1's
Form
Zovirax oral susp 200 mg/5 mL
Packing/Price
125 mL x 1's
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