Aceclofenac: May increase plasma conc of lithium & digoxin. Increased nephrotoxicity w/ diuretics. Monitor when used w/ K-sparing diuretics. May enhance activity of anticoagulants. May increase plasma methotrexate levels leading to toxicity w/in 2-4 hr of methotrexate administration. Risk of convulsions w/ quinolones. Paracetamol: Reduced absorption of cholestyramine (w/in 1 hr). Accelerated absorption w/ metoclopramide. Increased risk of liver damage in chronic alcoholics. Increased risk of toxicity w/ high dose, long-term use of barbiturates, carbamazepine, hydantoins, INH, rifampicin & sulfinpyrazone.