Amalvex

Amalvex

amlodipine

Manufacturer:

Hiral Labs

Distributor:

Mc Graw Pharma

Marketer:

AGlobal Care
Concise Prescribing Info
Contents
Amlodipine besilate
Indications/Uses
HTN, chronic stable angina pectoris & vasospastic (Prinzmetal's) angina.
Dosage/Direction for Use
Adult HTN & angina Initially 5 mg once daily, may be increased to a max of 10 mg. Childn & adolescent 6-17 yr HTN 2.5 mg once daily, up-titrated to 5 mg once daily if BP goal is not achieved after 4 wk.
Administration
May be taken with or without food: Avoid grapefruit or grapefruit juice.
Contraindications
Hypersensitivity to dihydropyridine derivatives or amlodipine. Severe hypotension, shock (including cardiogenic shock), obstruction of the outflow tract of the left ventricle (eg, high grade aortic stenosis), haemodynamically unstable heart failure after cute MI.
Special Precautions
Hypertensive crisis. Patients w/ heart failure & CHF. Hepatic impairment. Pregnancy & lactation. Childn <6 yr. Elderly.
Adverse Reactions
Somnolence, dizziness, headache; palpitations; flushing; abdominal pain, nausea; ankle swelling; oedema, fatigue.
Drug Interactions
Increased exposure w/ strong or moderate CYP3A4 inhibitors [PIs, azole antifungals, macrolides (eg, erythromycin or clarithromycin), verapamil or diltiazem]. May lower plasma conc w/ CYP3A4 inducers (eg, rifampicin, Hypericum perforatum). Increased BP lowering effects w/ grapefruit or grapefruit juice & other medicinal products w/ antihypertensive properties. Risk of hyperkalemia w/ verapamil & IV dantrolene.
MIMS Class
Calcium Antagonists / Anti-Anginal Drugs
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Amalvex tab 10 mg
Packing/Price
100's
Form
Amalvex tab 5 mg
Packing/Price
100's
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