Yichang Humanwell


Endure Medical
Concise Prescribing Info
Anesth & intensive care to reverse benzodiazepine-induced sedation. Benzodiazepine overdose.
Dosage/Direction for Use
IV Reversal of benzodiazepine-induced sedation 200 mcg  by slow IV inj or infusion followed by 60-sec interval of 100-200 mcg further doses. Max total dose: 1 or 2 mg. Each dose be given over 15 sec & further doses be given only if no adequate response 45 sec after completion of inj. Recurrent drowsiness 100-400 mcg/hr IV infusion. Alternatively, further doses up to 1 mg, in 200 mcg bolus at 20-min interval. Max: 3 mg in 1 hr. Patients at risk from benzodiazepine reversal effect 100 mcg bolus inj. Childn 10 mcg/kg IV over 15 sec repeated at 60-sec interval. Max: 50 mcg/kg or 1 mg, w/ further dose if no adequate response after 45 sec after completion of inj. Benzodiazepine overdose Initially 200 mcg IV over 30 sec, further dose of 300 mcg after another 30 sec followed by 500 mcg at 1-min interval. Total dose: 3 mg up to max of 5 mg.  May repeat dose at 20-min interval if symptoms of intoxication recurs; not >1 mg should be given at any 1-time & not >3 mg in 1 hr.
Neuromuscular blockers. High risk or anxious patients & after major surgery; head injury. Hepatic impairment.
Special Precautions
May unmask adverse effects of other psychotrophic drugs. Not to be used during severe intoxication w/ TCAs & related antidepressants.
Adverse Reactions
Nausea, vomiting, dizziness, blurred vision, headache & flushing; anxiety, fear, agitation; seizures; transient increase in BP & heart rate.
Drug Interactions
Not to be used in patients exhibiting manifestations of serious concurrent cyclic antidepressant overdosage. May precipitate dose-dependent manifestations of w/drawal w/ benzodiazepine. Opiates, inhalational anesth, skeletal muscle relaxants or muscle relaxant antagonist; neuromuscular blockage.
ATC Classification
V03AB25 - flumazenil ; Belongs to the class of antidotes. Used in the management of hypnotics and sedatives overdose.
Anzenil soln for infusion 100 mcg/mL
5 mL x 5 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in