Discontinue treatment in cases of anaphylactic reactions. Avoid treatment in patients w/ known prolongation of the QT interval & uncorrected hypokalemia; receiving class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic agents. Patients treated concomitantly w/ drugs that prolong the QT interval eg, cisapride, erythromycin, antipsychotics & TCAs; w/ ongoing proarrhythmic conditions eg, clinically significant bradycardia, acute myocardial ischemia, & liver cirrhosis; in women & elderly who are more susceptible to QTc-prolonging drugs. Fulminant hepatitis, symptoms related to liver failure. Patients w/ known or suspected CNS disorders (eg, lowered convulsion threshold, previous history of convulsion, reduced cerebral blood flow, altered brain structure or stroke), which may predispose to seizures or lower seizure threshold. Antibiotic-associated colitis; patients who develop serious diarrhoea in association w/ use. Myasthenia gravis. Tendinitis & tendon rupture in elderly, during strenuous physical activity, in patients treated concomitantly w/ corticosteroids, in patients w/ renal impairment including renal failure & patients w/ solid organ transplants. Not recommended for the treatment of MRSA infections. May interfere w/ Mycobacterium
spp culture test. Peripheral neuropathy. Discontinue use if the patient develops psychiatric reactions. Psychotic patients or patients w/ history of psychiatric disease. Avoid in patients w/ pelvic inflammatory disease, unless fluoroquinolone-resistant N. gonorrhoeae
can be excluded. Dysglycemia in elderly diabetic patients receiving concomitant treatment w/ oral hypoglycemic agent (eg, sulfonylurea) or w/ insulin. Careful monitoring of blood glucose in diabetic patients. Aortic aneurysm & dissection particularly in older population. May result in impairment of ability to drive or operate machinery due to CNS reactions & vision disorders. Adolescent & childn. Tab: Not recommended in patients w/ complicated pelvic inflammatory disease (eg, associated w/ tubo-ovarian or pelvic abscess). Soln for infusion: Na intake in patients w/ CHF, renal failure, nephrotic syndrome.