Cases of mental confusion, euphoria, agitation & disturbed behavior. Risk of central anticholinergic syndrome. Patients w/ glaucoma, prostatism, epilepsy, cardiac arrhythmia, heart failure, cardiac surgery, acute MI & HTN. Do not give in patients w/ angle-closure glaucoma or w/ narrow angle between iris & cornea. May raise IOP & precipitate acute attack. Caution in conditions characterised by tachycardia eg, thyrotoxicosis, heart failure & in cardiac surgery, where they may further accelerate heart rate. Reduced bronchial secretion. Avoid abrupt w/drawal. May impair ability to drive or operate machinery. Childn. Elderly.