Gufic Biosciences


Concise Prescribing Info
Omeprazole sodium
Duodenal ulcer; gastric ulcer; reflux esophagitis & esophageal ulceration; Zollinger-Ellison syndrome; resistant ulcer; eradication of H. pylori in combination w/ antibiotics.
Dosage/Direction for Use
IV Prophylaxis of acid aspiration 40 mg completed 1 hour before surgery. Benign gastric ulcer, duodenal ulcer & gastroesophageal reflux 40 mg once daily until oral administration. Possible severe peptic ulcer bleeding (unlicensed indication) Initially 80 mg by IV infusion, then 8 mg/hr by continuous IV infusion for 72 hr. Patient unsuited to receive oral therapy 40 mg of the base over a period of 20-30 min on a short-term basis by IV infusion. May also be given by slow IV inj. Childn 1 mth-12 yr 500 mcg/kg (max of 20 mg) once daily. May be increased to 2 mg/kg (max of 40 mg) once daily if needed. Administration: IV inj over 5 min, or by IV infusion over 20-30 min.
Hypersensitivity to omeprazole & other substituted benzimidazoles (rabeprazole, esomeprazole).
Special Precautions
Atrophic gastritis in long-term treatment; patients w/ various degrees/types of hepatic disease. Pregnancy & lactation. Childn <2 yr. Elderly.
Adverse Reactions
Headache, diarrhoea & skin rashes; pruritus, dizziness, fatigue, constipation, nausea & vomiting, flatulence, abdominal pain, arthralgia & myalgia, urticaria & dry mouth; hypersensitivity reactions; insomnia, somnolence & vertigo; reversible confusional states, agitation, depression & hallucinations; raised liver enzymes; increased risk of GI infections.
Drug Interactions
May affect azole antifungal agents (eg, itraconazole, ketoconazole), benzodiazepines, cilostazol, clarithromycin, digoxin, phenytoin, salicylates, sulfonylureas & warfarin; cyclosporine, disulfiram, azole antifungal agents, hydantoins. May interfere absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, ampicillin, Fe salts, digoxin, cyanocobalamin). May affect omeprazole w/ clarithromycin & sucralfate.
ATC Classification
A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Bloxid powd for inj 40 mg
((+ 10 mL diluent in amp)) 1's
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