Drowsiness, dry mouth, dizziness, and headache commonly occur during the initial stages of therapy with Clonidine. Constipation is common, and other adverse effects that have been reported include depression, anxiety, fatigue, nausea, anorexia, parotid pain, sleep disturbances, vivid dreams, impotence and loss of libido, urinary retention or incontinence, orthostatic hypotension, and dry, itching, or burning sensations in the eye. Fluid retention may occur and is usually transient, but may be responsible for a reduction in the hypotensive effect during continued treatment. Clonidine may cause rashes and pruritus, and these are more common with the use of transdermal delivery systems. Less frequently, bradycardia, including sinus bradycardia with atrioventricular block, other ECG disturbance, heart failure, hallucinations, cramp, Raynaud's syndrome, gynaecomastia, and transient abnormalities, in liver function test have been reported. Large doses have been associated with initial increases in blood pressure and transient hyperglycemia, although these do not persist during continued therapy.
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