12.5 mg once or bid on the 1st day followed by 25 mg once or bid on the 2nd day. Thereafter, may gradually increase in steps of 25-50 mg to achieve a daily dose of up to 300 mg w/in 14-21 days. Subsequent increases in steps of 50-100 mg may be made once or twice wkly; max: 900 mg daily. Maintenance: 200-450 mg daily. Total daily dose should be given in divided doses. Daily maintenance of ≤200 mg may be given as a single dose in the evening. Elderly
Initially 12.5 mg on the 1st day & subsequent dose increments should be restricted to 25 mg. Patient who are re-starting treatment after an interval of >2 days
12.5 mg once or bid on the 1st day.