Coumadin

Coumadin

warfarin

Manufacturer:

Taro

Distributor:

Zuellig

Marketer:

A. Menarini
Concise Prescribing Info
Contents
Warfarin Na
Indications/Uses
Prophylaxis & treatment of venous thrombosis, atrial fibrillation w/ embolization, pulmonary embolism, adjunct in prophylaxis of systemic embolism after MI & in treatment of coronary occlusion.
Dosage/Direction for Use
Individualized dosage & duration of treatment. Initially 2-5 mg daily. Maintenance: 2-10 mg daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Hemorrhagic tendency or blood dyscrasias. Recent or contemplated surgery of CNS, eye or traumatic surgery resulting in large open surfaces. Bleeding tendencies associated w/ active ulceration or overt bleeding of GI, genitourinary or resp tracts; cerebrovascular hemorrhage; cerebral aneurysms, dissecting aorta; pericarditis & pericardial effusions; bacterial endocarditis. Threatened abortion, eclampsia & preeclampsia. Unsupervised patients w/ senility, alcoholism, psychosis or lack of patient cooperation. Spinal puncture. Major regional, lumbar block anesth, malignant HTN. Pregnancy.
Special Precautions
Any predisposing condition where added risk of hemorrhage, necrosis &/or gangrene is present. Determine prothrombin time/INR or other suitable coagulation tests periodically. Known or suspected hereditary, familial or clinical deficiency in protein has been associated w/ an increased risk of developing necrosis during warfarin administration. Discontinue use when systemic cholesterol microembolization including "purple toes syndrome" occurs. Patients w/ heparin-induced thrombocytopenia & DVT. Severe elevation in activated partial thromboplastin time (>50 sec). Severe to moderate HTN, hepatic or renal insufficiency. Infectious diseases or disturbances of intestinal flora. Surgery or trauma. Indwelling catheters. Polycythemia vera, vasculitis & severe diabetes. CHF. Concomitant use w/ streptokinase or urokinase. Women of childbearing potential. Lactation. Childn <18 yr. Elderly ≥60 yr.
Adverse Reactions
Fatal or non-fatal hemorrhage, bleeding, necrosis of skin & other tissues.
Drug Interactions
Antiarrhythmics, oral aminoglycosides, parenteral cephalosporins, macrolides, high-dose IV penicillins, quinolones, long-acting sulfonamides, tetracyclines, anticonvulsants, antidepressants, antineoplastics, antithyroid drugs, diuretics, systemic fungal medications, gastric acidity & peptic ulcer agents, hypnotics, bile acid binding resins, adrenocortical steroids, TB agents, vit. Bromelains, danshen, dong quai (Angelica sinensis), garlic, Ginkgo biloba, ginseng, cranberry products; co-enzyme Q10 & St. John's wort.
ATC Classification
B01AA03 - warfarin ; Belongs to the class of vitamin K antagonists. Used in the treatment of thrombosis.
Presentation/Packing
Form
Coumadin tab 2.5 mg
Packing/Price
100's (P31/tab)
Form
Coumadin tab 1 mg
Packing/Price
100's (P24.5/tab)
Form
Coumadin tab 5 mg
Packing/Price
100's (P42.5/tab)
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