Concise Prescribing Info
Losartan K
HTN. Reduction in the risk of CV morbidity & mortality in hypertensive patients w/ left ventricular hypertrophy. Treatment of diabetic nephropathy w/ an elevated serum creatinine & proteinuria in patients w/ type 2 diabetes & a history of HTN.
Dosage/Direction for Use
HTN 50 mg once daily, may be increased to 100 mg once daily. Patient w/ intravascular vol-depletion 25 mg once daily. Reduction in the risk of CV morbidity & mortality in patient w/ left ventricular hypertrophy 50 mg once daily. A low dose of hydrochlorothiazide should be added &/or the dose of losartan K should be increased to 100 mg once daily based on BP response. Nephropathy in type 2 diabetic patient w/ proteinuria 50 mg once daily, may be increased to 100 mg once daily.
May be taken with or without food.
Hypersensitivity. Co-administration of aliskiren in patients w/ diabetes. Pregnancy.
Special Precautions
Patients who are intravascularly vol-depleted. Concomitant use of other drugs that may increase K may lead to hyperkalemia. History of hepatic impairment. Other drugs that affect RAAS may increase blood urea & serum creatinine in patients w/ bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Black patients. Pregnancy & lactation. Neonates w/ history of in utero exposure to losartan.
Adverse Reactions
Dizziness, asthenia/fatigue, & vertigo.
Drug Interactions
Reduced levels of active metabolite w/ rifampicin & fluconazole. Increase in serum K w/ K-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements, K-containing salt substitutes or other drugs that may increase serum K (eg, trimethoprim-containing products). May reduce lithium excretion. May reduce effect w/ NSAIDs including selective COX-2 inhibitors. Increased risks of hypotension, syncope, hyperkalemia & changes in renal function w/ angiotensin receptor blockers, ACE inhibitors & aliskiren.
MIMS Class
Angiotensin II Antagonists
ATC Classification
C09CA01 - losartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.
Cozaar tab 100 mg
30's (P680/pack)
Cozaar tab 50 mg
30's (P579/pack)
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