In pediatric OCD patients, side-effects which occurred significantly are headache, insomnia, agitation, anorexia and tremor. Most were of mild to moderate severity.
The following adverse reactions of sertraline have been reported: Cardiovascular:
Blood pressure disturbances including postural hypotension, tachycardia.
Vomiting, abdominal pain.
Amnesia, headache, drowsiness, movement disorders paraesthesia, hypoaesthesia, depressive symptoms, hallucinations, aggressive reaction, agitation, anxiety, psychosis, depersonalisation nervousness, panic reaction and signs and symptoms associated with serotonin syndrome which include fever, rigidity, confusion, agitation, diaphoresis, tachycardia hypertension and diarrhea.
Convulsions (Seizures): Sertraline should be discontinued in any patient who develops seizures.
Rarely, pancreatitis and serious liver events including hepatitis, jaundice and liver failure. Asymptomatic elevations in serum transaminsases (SGOT and SGPT) have been reported in association with sertraline administration (0.8-1.3%), with an increased risk associated with the 200 mg daily dose. The abnormalities usually occurred within the first 1-9 weeks of drug treatment and promptly diminished upon drug discontinuation.
Renal & urinary disorders:
Hyperprolactinemia, galactorrhea, menstrual irregularities, anorgasmy.
Skin and allergic reactions:
Rash (including rare reports of erythema multiforme, photosensitivity), angioedema, ecchymoses, pruritus and anaphylactoid reactions.
Rare cases of hyponatremia have been reported and appeared to be reversible when sertraline was discontinued.
There have been rare reports of altered platelet function and/or abnormal clinical laboratory results in patients taking sertraline.
Withdrawal reactions have been reported with sertraline. Common symptoms include dizziness, paraesthesia, headache, anxiety and nausea. Abrupt discontinuation of treatment with Sertraline should be avoided. The majority of symptoms experience on withdrawal of sertraline are non-serious and self-limiting.