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Indications and Dosage
Oral
Minor infections of the mouth and throat Adult: Suck 1 loz (0.25 mg) up to 6 times daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines). Vaginal Bacterial vaginosis Adult: Insert 1 vaginal tab (10 mg) once daily at bedtime for 6 days. Interrupt treatment during menstruation and resume afterwards.
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Contraindications
Vaginal tab: Hypersensitivity. Ulceration of the vaginal epithelium and the vaginal portion of the cervix.
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Special Precautions
Avoid the use of vaginal tab within 12 hours before birth. Vaginal tab is not indicated for use prior to menarche. Pregnancy and lactation.
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Adverse Reactions
Gastrointestinal disorders: Glossalgia (loz).
General disorders and administration site conditions: Fever (vaginal tab). Reproductive system and breast disorders: Vaginal discharge or candidiasis, vulvovaginal pruritus or burning sensation (vaginal tab). |
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Patient Counseling Information
Vaginal tab: Use a sanitary towel or pantyliner following administration. Avoid the use of non-latex condoms and other intravaginal devices for at least 12 hours following the treatment.
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Drug Interactions
Anionic substances (e.g. soaps, vaginal wash, detergents, surfactants) may reduce the antimicrobial activity of dequalinium vaginal tab; avoid concomitant use.
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Action
Description: Dequalinium is a quaternary ammonium anti-infective agent against gram-positive and gram-negative bacteria, fungi and yeasts. It increases bacterial cell permeability and reduces enzymatic activity, thus causing cell death.
Onset: 30-60 minutes (vaginal tab). |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2993, Dequalinium. https://pubchem.ncbi.nlm.nih.gov/compound/Dequalinium. Accessed June 27, 2022. |
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Storage
Store below 30°C.
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ATC Classification
G01AC05 - dequalinium ; Belongs to the class of quinolone derivative antiinfectives. Used in the treatment of gynecological infections.
R02AA02 - dequalinium ; Belongs to the class of antiseptics used in throat preparations. |
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References
Anon. Dequalinium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/03/2022. Buckingham R (ed). Dequalinium Chloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/03/2022. Dequa Lozenges (Dynapharm [M] Sdn. Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 16/03/2022. Dequadin Lozenges (Sterling Drug [M] Sdn Bhd). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 16/03/2022. Fluomizin 10 mg Vaginal Tablets (Kora Corporation Ltd). MHRA. https://products.mhra.gov.uk. Accessed 16/03/2022. Fluomizin Vaginal Tablets (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 16/03/2022. Joint Formulary Committe. Dequalinium Chloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/03/2022.
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