Diiodohydroxyquinoline


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Bacterial skin infections, Skin fungal infections
Adult: Apply to affected area(s) 3-4 times daily.
Child: >12 years Same as adult dose.
Contraindications
Hypersensitivity.
Special Precautions
Patient with thyroid abnormalities. Children. Pregnancy and lactation. Prolonged use.
Adverse Reactions
Significant: Hypersensitivity reactions, overgrowth of nonsusceptible organisms (prolonged use).
Patient Counseling Information
Avoid contact with eyes. Avoid use with occlusive dressing. May cause discolouration of skin, hair and dyed fabrics.
Lab Interference
May interfere with thyroid function test. May give false-positive ferric chloride test for phenylketonuria.
Action
Description: Diiodohydroxyquinoline is a halogenated 8-hydroxyquinoline, an amoebicide with antifungal and antibacterial properties. It chelates trace metals at bacterial surfaces, which are essential for bacterial growth. Synonym: iodoquinol.
Pharmacokinetics:
Absorption: Absorbed systemically through the skin.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Iodoquinol, CID=3728, https://pubchem.ncbi.nlm.nih.gov/compound/Iodoquinol (accessed on Jan. 21, 2020)

Storage
Store between 20-25°C.
ATC Classification
G01AC01 - diiodohydroxyquinoline ; Belongs to the class of quinolone derivative antiinfectives. Used in the treatment of gynecological infections.
References
Aloquin Gel (Primus Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 03/05/2018.

Anon. Iodoquinol (Topical). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 03/05/2018.

Anon. Iodoquinol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/05/2018.

Buckingham R (ed). Diiodohydroxyquinoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/05/2018.

Quinja Gel (Novum Pharma, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 03/05/2018.

Disclaimer: This information is independently developed by MIMS based on Diiodohydroxyquinoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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