Dilzem

Dilzem

diltiazem

Manufacturer:

Pfizer

Distributor:

Zuellig
Concise Prescribing Info
Contents
Diltiazem HCl
Indications/Uses
Unstable angina pectoris including angina due to coronary artery spasm or following MI. Management of chronic stable angina in patients who cannot tolerate therapy w/ β-blockers &/or nitrates or those remain symptomatic despite adequate doses of these agents. In HTN, either alone or in combination w/ other antihypertensives eg, diuretics. Prevention of graft failure following kidney transplantation.
Dosage/Direction for Use
Ischemic heart disease (exertional angina pectoris due to atherosclerotic coronary artery disease or angina pectoris at rest due to coronary artery spasm Initially 120 mg/day in equally divided doses. Gradually increase in equally divided doses (bid or qid) at 1-2 day interval. Optimum dose range: 180-360 mg/day in divided doses. HTN Initially 120-240 mg/day in equally divided doses. Usual dose range: 240-360 mg/day. Kidney transplantation Initially 120 mg/day in 2 equally divided doses. Max: 360 mg/day in 3 equally divided doses. Optimum dose range: 180-360 mg/day.
Administration
Should be taken on an empty stomach: Preferably taken before meals & at bedtime. SA & SR tab: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity. Sick sinus syndrome, 2nd- or 3rd-degree AV block, hypotension (<90 mmHg systolic), acute MI, X-ray documented pulmonary congestion.
Special Precautions
Prolongs AV node refractory periods w/o significantly prolonging sinus node recovery time, except in patients w/ sick sinus syndrome. Concomitant use w/ β-blockers or digitalis. Patients w/ impaired ventricular, renal or hepatic function. Symptomatic hypotension. Monitor liver & kidney lab parameters at regular intervals. Discontinue if dermatological reactions persist. Pregnancy & lactation.
Adverse Reactions
Headache, dizziness; 1st degree AV block, sinus bradycardia; flushing; nausea; rash; joint swelling; asthenia, fatigue, edema.
Drug Interactions
Additive effects on cardiac conduction w/ β-blockers or digitalis. Increased exposure  of ivabradine (Cmax, AUC). Increased bioavailability of propranolol. Increased plasma levels and AUC w/ cimetidine. Increased plasma levels of ciclosporin & carbamazepine. Concurrent use w/ erythromycin may cause risk for heart irregularities for those w/ long QT manifestations. Increase AUC of statins. May increase everolimus blood conc. Digoxin, anesth, warfarin, rifampin or lithium.
MIMS Class
ATC Classification
C08DB01 - diltiazem ; Belongs to the class of benzothiazepine derivative selective calcium-channel blockers with direct cardiac effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Dilzem SR tab 180 mg
Packing/Price
60's (P7,253.34/pack)
Form
Dilzem SA tab 90 mg
Packing/Price
60's (P4,874.67/pack)
Form
Dilzem tab 30 mg
Packing/Price
200's (P7,307.7/pack)
Form
Dilzem tab 60 mg
Packing/Price
200's (P10,399.76/pack)
Form
Dilzem OD tab 120 mg
Packing/Price
60's (P5,376.58/pack)
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