Treatment of edema associated w/ heart failure & renal hepatic disorders. HTN, either alone or together w/ other antihypertensives eg, ACE inhibitors & β-blockers. Treatment of edema accompanying premenstrual syndrome, prevention of water retention associated w/ corticosteroids & estrogens, treatment of diabetes insipidus & prevention of renal calculus formation in patients w/ hypercalciuria.
Dosage/Direction for Use
Edema Usual dose: 25-100 mg daily, up to 200 mg daily (for severe cases). Reduced to 25-50 mg daily or intermittently. Nephrogenic diabetes insipidus Up to 100 mg daily. HTN Usual dose: 25-50 mg daily. Childn 1-2 mg/kg daily in 2 divided doses. Infant <6 mth Up to 3 mg/kg daily.
Administration
Should be taken with food.
Contraindications
Pregnancy & lactation. Patients w/ severe renal impairment or anuria, Addison's disease, preexisting hypercalcemia.
Special Precautions
Patients w/ renal impairment, existing fluid & electrolyte disturbances. Elderly. May precipitate attacks of gout, cause hyperglycemia & aggravate or unmask DM.
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