Dopamet Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Methyldopa sesquihydrate

Indications/Uses

HTN; drug of choice during pregnancy.

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Dosage/Direction for Use

Adult Initially 250 mg bid-tid, increased gradually at intervals of ≥2 days. Max dose: 3 g daily. Maintenance dose: 500 mg to 2 g daily. Elderly Initially125 mg bid. Max dose: 2 g daily.

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Administration

May be taken with or without food.

Special Precautions

Patients w/ impaired renal or hepatic function or history of hemolytic anemia, active liver disease or depression. Not recommended for phaechromocytoma. May produce +ve direct Coombs' test. May cause sedation affecting ability to drive or operate machinery.

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Adverse Reactions

Drowsiness, dizziness & lightheadedness associated w/ postural hypotension. Fluid retention & edema. Mental neurological effects eg, impaired conc & memory, mild psychosis, depression, disturbed sleep & nightmares, paresthesias, Bell's palsy, involuntary choreoathetopic movements & parkinsonism. GI disturbances eg, nausea & vomiting, diarrhea, constipation; black/sore tongue, inflammation of salivary glands, dry mouth. Hypersensitivity effects eg, myocarditis, fever, eosinophilia, liver function disturbances. Rashes, lichenoid, granulomatous eruptions, toxic epidermal necrolysis, flu-like syndrome, nocturia, uraemia, nasal congestion, retroperitoneal fibrosis.

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Drug Interactions

Hypotension effects may be potentiated by diuretics, other antihypertensives & drugs w/ hypertensive effects. Paradoxical antagonism of hypotensive effects by TCAs, antipsychotics, β-blockers; sympathomimetics. Concomitant use w/ MAOIs & general anesth. May inihbit metabolism w/ entacapone.

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Storage

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Description

View Dopamet description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Other Antihypertensives

ATC Classification

C02AB01 - methyldopa (levorotatory) ; Belongs to the class of methyldopa, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.

Regulatory Classification

Presentation/Packing

Form

Dopamet film-coated tab 250 mg

Packing/Price

40's (P487.5/pack);80's

Dopamet

methyldopa

Manufacturer:

Lloyd

Distributor:

Solvang