Endo-Pro

Endo-Pro

lidocaine

Manufacturer:

Swiss Parenterals

Distributor:

Endure Medical
Concise Prescribing Info
Contents
Lidocaine HCl
Indications/Uses
Infiltration anaesth & regional nerve blocks; surface anaesth. Treatment of ventricular arrhythmias, especially after MI; refractory status epilepticus via IV infusion.
Dosage/Direction for Use
Percutaneous infiltration anaesth 5-300 mg (1-60 mL of 0.5% soln or 0.5-30 mL of 1% soln). Peripheral nerve block based on the route of administration: Brachial plexus block 225-300 mg (15-20 mL) as 1.5% soln; intercostal nerve block 30 mg (3 mL) as 1% soln; paracervical block 100 mg (10 mL) of 1% soln on each side every 90 min; paravertebral block 1% soln of 30-50 mg (3-5 mL); pudendal block 1% soln of 100 mg (10 mL) on each side; retrobulbar block 4% soln of 120-200 mg (3-5 mL). Sympathetic nerve block 1% soln: cervical block 50 mg (5 mL), lumbar block 50-100 mg (5-10 mL). Epidural anaesth 2-3 mL of soln for each dermatone to be anaesthetised. Lumbar epidural 250-300 mg (25-30 mL) as 1% soln for analgesia & 225-300 mg (15-20 mL) as 1.5% soln or 200-300 mg (10-15 mL) as 2% soln for anaesth. Thoracic epidural 1% soln of 200-300 mg (20-30 mL). Obstet caudal analgesia 200-300 mg (20-30 mL) as 1% soln. Surgical caudal anaesth 1.5% soln of 225-300 mg (15-20 mL). Continuous epidural anaesth Max doses should not be repeated more frequently than every 90 min. IV regional anaesth 0.5% soln of 50-300 mg (10-60 mL) w/ max dose of 4 mg/kg. Ventricular arrhythmias Adult 1-1.5 mg/kg IV & repeated after 3-5 min to a total dose of 3 mg/kg if necessary. Patients in a more stable condition are given a loading dose followed by an infusion. Usual doses are 50-100 mg or 1-1.5 mg/kg as direct IV inj at a rate of 25-50 mg/min. If no effect is seen w/in 5-10 min, it may be repeated once or twice to max dose of 200-300 mg in 1 hr. Continuous IV infusion is commenced after loading, at a dose of 1-4 mg/min. Arrhythmia in emergency situations 300 mg IM inj into the deltoid muscle, repeated after 60-90 min if necessary.
Contraindications
Hypersensitivity. Should not be given to patients w/ hypovolaemia, heart block or other conduction disturbances. Should not be inj into or applied to inflamed or infected tissues or to damaged skin or mucosa.
Special Precautions
Patients w/ CHF, bradycardia or resp depression; debilitated patients; epilepsy; impaired cardiac conduction or resp function, shock. IM inj may increase creatinine phosphokinase conc that can interfere w/ the diagnosis of acute MI. Hepatic impairment. Childn. Elderly.
Adverse Reactions
Restlessness, excitement, nervousness, paraesthesias, dizziness, tinnitus, blurred vision, nausea & vomiting, muscle twitching & tremors, convulsions. Numbness of the tongue & perioral region, lightheadedness followed by sedation. Depression w/ drowsiness, resp failure & coma. Hypotension & bradycardia; arrhythmias & cardiac arrest. Methaemoglobinaemia.
Drug Interactions
May competitively enhance neuromuscular blocking activity of suxamethonium. Increased risk of myocardial depression w/ antiarrhythmics. Reduced clearance w/ propranolol & cimetidine. Additive cardiac depressant effects w/ β-blockers & other antiarrhythmics including IV phenytoin. May produce hypokalemia w/ acetazolamide, loop diuretics & thiazides.
ATC Classification
N01BB02 - lidocaine ; Belongs to the class of amides. Used as local anesthetics.
Presentation/Packing
Form
Endo-Pro soln for inj 20 mg/mL (2% w/v)
Packing/Price
50 mL x 1's
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