Concise Prescribing Info
Cefoxitin Na
Lower resp tract, intra-abdominal, gynecological, bone & joint, skin & skin structure infections, UTI, septicemia.
Dosage/Direction for Use
Adult 1-2 g every 6-8 hr. Uncomplicated infection (eg, pneumonia, UTI, cutaneous infection) 1 g IV every 6-8 hr. Daily dosage: 3-4 g. Moderately severe or severe infection 1 g IV every 4 hr or 2 g IV every 6-8 hr. Daily dosage: 6-8 g. Infections commonly needing antibiotics in higher dosage (eg, gas gangrene) 2 g IV every 4 hr or 3 g IV every 6 hr. Daily dosage: 12 g. Renal insufficiency Initial loading dose: 1-2 g. Patient undergoing hemodialysis 1-2 g after each hemodialysis. Mild impairment (CrCl 50-30 mL/min) 1-2 g every 8-12 hr, moderate impairment (CrCl 29-10 mL/min) 1-2 g every 12-24 hr; severe impairment (CrCl 9-5 mL/min) 0.5-1 g every 12-24 hr; essentially no function (CrCl <5 mL/min) 0.5-1 g every 24-48 hr. Childn ≥3 mth 80-160 mg/kg/day divided into 4-6 equal doses. Max: 12 g/day. Post-op prophylaxis Administer ½-1 hr prior to surgery. Prophylaxis in uncontaminated GI surgery, vag hysterectomy, abdominal hysterectomy Adult 2 g every 6 hr for not >24 hr. Cesarean section 2 g IV as soon as the umbilical cord is clamped or 3-dose regimen consisting of 2 g IV as soon as the umbilical cord is clamped followed by 2 g 4 & 8 hr after the initial dose. Childn ≥3 mth 30-40 mg/kg may be given at the same time intervals as adult.
Hypersensitivity to cephalosporins.
Special Precautions
Penicillin-sensitive patients. Consider diagnosis of pseudomembranous colitis in patients w/ diarrhea. History of GI disease eg, colitis. Prolonged use may result in overgrowth of nonsusceptible organisms. Periodic assessment of organ system functions including renal, hepatic & hematopoietic during prolonged therapy. May interfere w/ Jaffe reaction producing falsely high creatinine levels; false +ve reaction for glucose in the urine. Renal impairment. Pregnancy & lactation. Childn (from birth to 3 mth). Elderly.
Adverse Reactions
Local reactions following IV inj. Thrombophlebitis; rash, urticaria, flushing, pruritus, eosinophilia, fever, dyspnea, other allergic reactions including anaphylaxis, interstitial nephritis & angioedema; hypotension; diarrhea; possible exacerbation of myasthenia gravis; eosinophilia, leukopenia; transient elevations in SGOT, SGPT, serum LDH & serum alkaline phosphatase, jaundice; elevation in serum creatinine &/or BUN.
Drug Interactions
Increased nephrotoxicity w/ aminoglycosides.
MIMS Class
ATC Classification
J01DC01 - cefoxitin ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Foxitin powd for inj 1 g
(vial) 1's (P950.75/vial)
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