The most common adverse effect associated with furosemide therapy is fluid and electrolyte imbalance after either single large doses or prolonged administration. Other side effects are relatively uncommon and include allergy, nausea, diarrhea, blurred vision, dizziness, headache, pancreatitis, photosensitivity, skin rashes, muscle spasm and hypotension. Hyponatraemia, hypokalemia, & hypomagnesaemia, hypochloraemic alkalosis, increased calcium excretion, hypotension; less commonly nausea, gastro-intestinal disturbances, hyperuricaemia & gout; hyperglycemia, temporary increase in plasma cholesterol & triglyceride concentrations; rarely rashes, photosensitivity, & bone marrow depression (withdrawal treatment).
Injection: Body as a whole:
Excessive sweating, fever, headache, malaise.
Cardiac arrhythmias, circulatory collapse, disorders of cardiac rhythm, hypotension, ischemic complications in the elderly.
Dermatologic and hypersensitivity reactions:
Allergic reaction, anaphylactic shock, angioedema, bullous pemphigoid, dermatitis, erythema multiforme, exacerbation or activation of systemic lupus erythematosus, exfoliative dermatitis, itching, necrotizing angiitis, photosensitivity, pruritus, purpura, rash, Stevens-Johnson syndrome, systemic vasculitis, urticaria, transient pain at injection site after intramuscular injection.
Anorexia, constipation, cramping, dehydration, diarrhea, dry mouth, gastrointestinal drainage, nausea, oral and gastric irritation, pancreatitis, vomiting.
Acute urinary retention with overflow incontinence in elderly men; decreased glomerular filtration rate (GFR); increased risk of persistence of patent ductus arteriosus, calcium depletion and nephrocalcinosis/nephrolithiasis in premature infants; interstitial nephritis; obstructed micturition (e.g., uretostenosis, hydronephrosis); urinary bladder spasm; urinary frequency; prostatic hyperplasia; transient increases in creatinine and blood urea nitrogen (BUN).
Agranulocytosis (rare), anemia, aplastic anemia (rare), bone marrow depression (rare), eosinophilia, hemoconcentration, hemolytic anemia, hypovolemia, leukopenia, thrombocytopenia, thrombophilia, thrombophlebitis.
Distention of biliary tree which is already obstructed, hepatic encephalopathy in patients with hepatocellular insufficiency, increased liver transaminase and bile flow, intrahepatic cholestatic jaundice, jaundice, liver dysfunction, pancreatitis.
Fluid and electrolyte imbalance; glycosuria; gout; hyperglycemia; hyperuricemia; hypokalemia; hypomagnesemia; increased insulin requirements in diabetic patients; latent diabetes mellitus; aggravated pre-existing metabolic alkalosis (e.g., due to compensated liver cirrhosis); alterations in glucose tolerance possibly as a result of hypokalemia.
Elevations in the following:
blood glucose, serum cholesterol, triglyceride, total cholesterol, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol, serum uric acid levels.
Calf muscle spasm, flank and loin pain, muscle spasm, weakness.
Apathy, confusion, dizziness, drowsiness, lightheadedness, neuromuscular irritability, paresthesia, restlessness, tetany, vertigo, xanthopsia.
Blurred vision, visual impairment, deafness, reversible hearing impairment and tinnitus (rare), permanent tinnitus and impairment of hearing in patients with markedly reduced renal function or hypoproteinemia (e.g., in nephrotic syndrome).