The most frequently reported adverse effects are diarrhea, nausea, vomiting, abdominal pain, skin rashes, urticaria, and erythema multiforme, vaginitis, abnormal taste, headache, dizziness, tiredness and hot flushes. Hepatitis and cholestatic jaundice have been reported. The events may be severe, and occur predominantly in adult or elderly patients. Signs and symptoms usually occur during or shortly after treatment, but in some cases may not become apparent until several weeks after treatment has ceased. The hepatic events are usually reversible. A moderate rise in Aspartate transaminase and/or Alanine transaminase has been noted in patients treated with Clavulanate Potassium and Amoxicillin. The following adverse reactions have been reported for ampicillin class antibiotics and may occur with Clavulanate Potassium and Amoxicillin.
gastritis, stomatitis, glossitis, black "hairy" tongue, enterocolitis and pseudomembranous colitis.
skin rashes, urticaria, erythema multiforme, rare cases of Stevens-Johnson syndrome and less frequently exfoliate dermatitis and toxic epidermal necrolysis have been reported. Whenever such reactions occur Clavulanate Potassium and Amoxicillin should be discontinued. Serious and occasional fatal hypersensitivity (anaphylactic) reactions and angioneurotic oedema can occur with oral penicillin.
Haematopoietic and lymphatic:
Anaemia, thrombocytopenia, thrombocytopenic, purpura, eosinophilia, leucopenia and agranulocytosis have been reported during therapy with penicillin. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. A slight thrombocytosis was noted less than 1% of the patients treated with Clavulanate Potassium and Amoxicillin. Prolongation of bleeding time and prothrombin time have been reported less frequently.