Infen-25

Infen-25

dexketoprofen

Manufacturer:

Emcure Pharma

Distributor:

Macropharma Corp
Concise Prescribing Info
Contents
Dexketoprofen trometamol
Indications/Uses
Pain of mild to moderate intensity eg, musculo-skeletal pain, dysmenorrhoea, dental pain.
Dosage/Direction for Use
Administration
Should be taken on an empty stomach: Take 30 min before meals.
Contraindications
Hypersensitivity to dexketoptrofen or to any other NSAID. Attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic oedema in patients taking substances eg, aspirin or other NSAIDs; active or suspected or history of GI ulcer or chronic dyspepsia; GI bleeding or other active bleedings or bleeding disorders; Crohn's disease or ulcerative colitis; history of bronchial asthma; severe heart failure; moderate to severe renal dysfunction; severely impaired hepatic function; hemorrhagic diathesis & other coagulation disorders. Pregnancy (3rd trimester) & lactation period
Special Precautions
History of allergic conditions; history of oesophagitis, gastritis &/or peptic ulcer; patients who are receiving other therapy that interfered w/ haemostasis eg, warfarin or other coumarins or heparins; may cause glomerular nephritis, interstitial nephritis, renal papillary necrosis, nephrotic syndrome & acute renal failure. Discontinue in case of relevant increase in liver parameters, SGOT & SGPT. May mask symptoms of infectious diseases. Haematopoetic disorders, SLE or mixed connective tissue disease; impairment of hepatic, renal or cardiac function as well as in patients w/ other conditions predisposing to fluid retention; history of cardiac disease particularly w/ previous episodes of heart failure. Discontinue at the 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. History of HTN  &/or mild to moderate CHF; uncontrolled HTN, CHF, established ischaemic heart disease, peripheral arterial disease, &/or cerebrovascular disease; risk factors for CV disease eg, HTN, hyperlipidaemia, DM, smoking (for long-term treatment). Mild to moderate hepatic dysfunction. Patients receiving diuretic therapy or those who could develop hypovolaemia; mildly impaired renal function. May impair female fertility. Elderly. Childn & adolescents.
Adverse Reactions
Nausea &/or vomiting, abdominal pain, diarrhoea, dyspepsia.
Drug Interactions
May increase the risk of GI ulcers & bleeding w/ other NSAIDs, including high doses of salicylates (≥3 g/day). Increased risk of haemorrhagic effect of the oral anticoagulant. Increased blood lithium levels which may reach toxic values. Increased haematological toxicity of methotrexate. May reduce the effect of diuretics & antihypertensive drugs. Increased risk of bleeding w/ pentoxyfylline. Red cell line toxicity w/ zidovudine. Increased the hypoglycemic effect of sulfonylureas. Decrease antihypertensive effect of β-blockers.  Enhance nephrotoxicity of cyclosporin & tacrolimus. Increased plasma conc w/ probenecid. Increased plasma glycoside conc. May alter the efficacy of mifepristone. Increased risk of developing convulsions w/ quinolone antibiotics.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification
M01AE17 - dexketoprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.
Presentation/Packing
Form
Infen-25 FC tab 25 mg
Packing/Price
10's
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