History of allergic conditions; history of oesophagitis, gastritis &/or peptic ulcer; patients who are receiving other therapy that interfered w/ haemostasis eg, warfarin or other coumarins or heparins; may cause glomerular nephritis, interstitial nephritis, renal papillary necrosis, nephrotic syndrome & acute renal failure. Discontinue in case of relevant increase in liver parameters, SGOT & SGPT. May mask symptoms of infectious diseases. Haematopoetic disorders, SLE or mixed connective tissue disease; impairment of hepatic, renal or cardiac function as well as in patients
w/ other conditions predisposing to fluid retention; history of cardiac disease particularly w/ previous episodes of heart failure. Discontinue at the 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. History of HTN &/or mild to moderate CHF; uncontrolled HTN, CHF, established
ischaemic heart disease, peripheral arterial disease, &/or
cerebrovascular disease; risk factors for CV disease eg, HTN, hyperlipidaemia, DM, smoking (for long-term treatment). Mild to moderate hepatic dysfunction. Patients receiving diuretic therapy or those who could develop hypovolaemia; mildly impaired renal function. May impair female fertility. Elderly. Childn & adolescents.