Intravenous route. The 100 ml bottle is restricted to adults, adolescents and children weighing more than 33 kg. The 20 ml bottle is adapted to term newborn infants, infants, toddlers and children weighing less than 33 kg.
Posology: Dosing based on patient weight (please see the dosing table here as follows). (See Table 2).
Click on icon to see table/diagram/image
Severe renal insufficiency:
It is recommended, when giving paracetamol to patients with severe renal impairment (creatinine clearance ≤30 mL/min), to increase the minimum interval between each administration to 6 hours. In adults with hepatocellular insufficiency, chronic alcoholism, chronic malnutrition (low reserves of hepatic glutathione), dehydration: The maximum daily dose must not exceed 3 g.
Method of administration:
Take care when prescribing and administering INFULGAN to avoid dosing errors due to confusion between milligram (mg) and milliliter (mL), which could result in accidental overdose and death. Take care to ensure the proper dose is communicated and dispensed. When writing prescriptions, include both the total dose in mg and the total dose in volume.
The paracetamol solution is administered as a 15-minute intravenous infusion.
Patients weighing ≤10 kg:
The glass bottles of INFULGAN should not be hung as an infusion due to the small volume of the medicinal product to be administered in this population.
The volume to be administered should be withdrawn from the bottle and could be administered undiluted or diluted (from one to nine volumes diluent) in a 0.9% sodium chloride solution or 5% glucose solution and administered in 15-minute.
Use the diluted solution within the hour following its preparation (infusion time included).
A 5 or 10 ml syringe should be used to measure the dose as appropriate for the weight of the child and the desired volume. However, this should never exceed 7.5 ml per dose.
The user should be referred to the product information for dosing guidelines.
Text for the 20 ml and 100 ml bottles:
To remove solution, use a 0.8 mm needle (21 gauge needle) and vertically perforate the stopper at the spot specifically indicated. As for all solutions for infusion presented in glass bottle, it should be remembered that close monitoring is needed notably at the end of the infusion, regardless of administration route. This monitoring at the end of the perfusion applies particularly for central route infusion, in order to avoid air embolism.
Text for the 20 ml bottles:
INFULGAN of 20 ml bottle can also be diluted in a 0.9% sodium chloride solution or 5% glucose solution (from one to nine volumes diluent). In this case, use the diluted solution within the hour following its preparation (infusion time included).